Correction to: British Journal of Cancer (2009) 100, 1926–1936; doi:10.1038/sj.bjc.6605072

In reference to Figure 4D, the drug quercetin is clearly cytotoxic as a single agent in the ALL-SIL cell line, but its effect in combination with dexamethasone (DEX) is not synergistic as originally quoted. Rather, the combination of quercetin and DEX resulted in a small, though non-significant reduction in cytotoxicity. This is in contrast to resveratrol (Figure 4E), which demonstrated synergistic cytotoxicity in combination with DEX. This difference in the two agents is reflected in their connectivity map (CMAP) enrichment scores in Table 3, with quercetin showing a positive enrichment in contrast to the negative scores for resveratrol, LY-294002 and rapamycin. Both quercetin and resveratrol are polyphenols that activate the key metabolic regulator AMPK, but the results suggest that they are mechanistically different and are unlikely to be equally efficacious in combinatorial therapy with glucocorticoids in T-cell acute lymphoblastic leukaemia (T-ALL). Figure 4D and Table 3 from the original paper are reproduced for reference, below.