Chloroform and methanol root and shoot extracts of A. aspera showed good amount of antibacterial activity against Klebsiella sp. While pet. Ether (60-80°) root extract showed the activity against B. Substilis only antifungal activity of roots was found in extracts with pet ether, chloroform and methanol against fusarium sp. only. Methanol and Aqueous shoot extracts were weakly active against Pencillium. Phytophothora and Sclerouum sp. Results suggest that extract has significant antibacterial and antifungal activities against tested microorganisms. The present study justified the claimed uses of A. aspera in the traditional system of medicine to treat various infectious diseases.