Mediators InflammMediators of Inflammation0962-93511466-1861Hindawi Publishing Corporation184755962365589 S0962935194000657 10.1155/S0962935194000657 Research ArticleInhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist NairX.2 TodderudG.2 DavernL.2 LeeD.2 AruffoA.12 TramposchK. M.2 3005 First Avenue Seattle WA 98121 USA Bristol-Myers Squibb Pharmaceutical Research Institute 100 Forest Avenue Buffalo NY 14213 USA 199436459463Copyright © 1994 Hindawi Publishing Corporation.1994Hindawi Publishing Corporation

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The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to immune complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of immune complex mediated diseases.