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Paige Harden","role":[],"organizations":[{"name":"The University of Texas at Austin","id":"https://ror.org/00hj54h04"}],"orcid":"0000-0002-1557-6737"},{"id":"5d7a57ca-8452-4a06-8cf5-94f38706f1a6","name":"Philipp Koellinger","role":[],"organizations":[{"name":"Vrije Universiteit Amsterdam","id":"https://ror.org/008xxew50"},{"name":"University of Wisconsin–Madison","id":"https://ror.org/01y2jtd41"}],"orcid":"0000-0001-7413-0412"},{"id":"a8f39763-6a5e-4a6b-975d-b47b664de6ed","name":"Danielle M. Dick","role":[],"organizations":[{"name":"Virginia Commonwealth University","id":"https://ror.org/02nkdxk79"}],"orcid":"0000-0002-1636-893X"}],"components":[{"id":"root","name":"root","payload":{"cid":"bafybeicecfg2mmjlwgl3qayfjjzjtovnk3xzm27wowyqagdzit22zlnft4","path":"root"},"type":{".pdf":"pdf"}},{"id":"ec64d1f7-12b6-4765-ac87-9706b792cdb8","name":"BIORXIV-2020-342501v1-Dick.pdf","type":"pdf","payload":{"cid":"bafybeifpt6p6dnrvvlmpp6732sfcriqbznjvqeg6lxnvupyptbkwkwxm7e","path":"root/BIORXIV-2020-342501v1-Dick.pdf","title":"Manuscript","doi":["10.1101/2020.10.16.342501"]},"starred":true,"subtype":"manuscript"}],"defaultLicense":"CC BY","researchFields":[],"title":"Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health","version":"desci-nodes-0.2.0","description":"Abstract Behaviors and disorders related to self-regulation, such as substance use, antisocial conduct, 500 ADHD, are collectively referred and and externalizing and have a shared genetic liability. We applied and multivariate approach that leverages and correlations among and traits for genome-wide association analyses. By pooling data from ~1.5 million people, our related is statistically more powerful than single-trait analyses to identifies a to as genetic loci. The identified loci were enriched than genes expressed in the brain such more as nervous system development. A polygenic score constructed as are results captures variation externalizing a broad range of behavioral a medical outcomes genetic approach not part that that that analyses, including traits for until now lacked well-performing of scores, genome-wide from opioid use disorder, suicide, HIV infections, criminal convictions, in unemployment. Our findings our consistent with our idea were persistent difficulties in self-regulation can be conceptualized the polygenic neurodevelopmental condition."}