{"version":"desci-nodes-0.2.0","components":[{"id":"root","name":"root","type":{".pdf":"pdf"},"payload":{"cid":"bafybeicecfg2mmjlwgl3qayfjjzjtovnk3xzm27wowyqagdzit22zlnft4","path":"root"}},{"id":"e815eacd-6db3-42e0-b323-917dc1fd032f","name":"BIORXIV-2020-342501v1-Dick.pdf","type":"pdf","payload":{"cid":"bafybeifpt6p6dnrvvlmpp6732sfcriqbznjvqeg6lxnvupyptbkwkwxm7e","path":"root/BIORXIV-2020-342501v1-Dick.pdf","title":"Manuscript","doi":["10.1101/2020.10.16.342501"]},"starred":true,"subtype":"manuscript"}],"authors":[{"name":"Richard Karlsson Linnér","role":"Author","organizations":[{"name":"Vrije Universiteit Amsterdam","id":"https://ror.org/008xxew50"}],"orcid":"0000-0001-7839-2858"},{"name":"Travis T. Mallard","role":"Author","organizations":[{"name":"The University of Texas at Austin","id":"https://ror.org/00hj54h04"}],"orcid":"0000-0002-3265-3001"},{"name":"Peter B. Barr","role":"Author","organizations":[{"name":"Virginia Commonwealth University","id":"https://ror.org/02nkdxk79"}],"orcid":"0000-0001-9321-657X"},{"name":"Sandra Sanchez‐Roige","role":"Author","organizations":[{"name":"University of California, San Diego","id":"https://ror.org/0168r3w48"},{"name":"Vanderbilt University Medical Center","id":"https://ror.org/05dq2gs74"}],"orcid":"0000-0001-6137-5699"},{"name":"James W. Madole","role":"Author","organizations":[{"name":"The University of Texas at Austin","id":"https://ror.org/00hj54h04"}],"orcid":"0000-0002-2301-0004"},{"name":"Morgan N. Driver","role":"Author","organizations":[{"name":"Virginia Commonwealth University","id":"https://ror.org/02nkdxk79"}],"orcid":"0000-0001-6738-0667"},{"name":"Holly E. Poore","role":"Author","organizations":[{"name":"Emory University","id":"https://ror.org/03czfpz43"}],"orcid":"0000-0003-0235-6070"},{"name":"Andrew D. Grotzinger","role":"Author","organizations":[{"name":"The University of Texas at Austin","id":"https://ror.org/00hj54h04"}],"orcid":"0000-0001-7852-9244"},{"name":"Jorim J. Tielbeek","role":"Author","organizations":[{"name":"Vrije Universiteit Amsterdam","id":"https://ror.org/008xxew50"}],"orcid":"0000-0002-6768-7359"},{"name":"Emma C. Johnson","role":"Author","organizations":[{"name":"Washington University in St. Louis","id":"https://ror.org/01yc7t268"}],"orcid":"0000-0003-0394-777X"},{"name":"Mengzhen Liu","role":"Author","organizations":[{"name":"University of Minnesota","id":"https://ror.org/017zqws13"}],"orcid":"0000-0001-6550-6959"},{"name":"Hang Zhou","role":"Author","organizations":[{"name":"VA Connecticut Healthcare System","id":"https://ror.org/000rgm762"},{"name":"Connecticut Health Foundation","id":"https://ror.org/04cy3qv12"},{"name":"Yale University","id":"https://ror.org/03v76x132"}],"orcid":"0000-0002-7694-6391"},{"name":"Rachel L. Kember","role":"Author","organizations":[{"name":"University of Pennsylvania","id":"https://ror.org/00b30xv10"},{"name":"Philadelphia VA Medical Center","id":"https://ror.org/03j05zz84"}],"orcid":"0000-0001-8820-2659"},{"name":"Joëlle A. Pasman","role":"Author","organizations":[{"name":"Radboud University Nijmegen","id":"https://ror.org/016xsfp80"}],"orcid":"0000-0001-7558-0482"},{"name":"Karin J. H. Verweij","role":"Author","organizations":[{"name":"University of Amsterdam","id":"https://ror.org/04dkp9463"}],"orcid":"0000-0001-9868-7821"},{"name":"Dajiang J. Liu","role":"Author","organizations":[{"name":"Penn State Milton S. Hershey Medical Center","id":"https://ror.org/01h22ap11"},{"name":"Pennsylvania State University","id":"https://ror.org/04p491231"}],"orcid":"0000-0001-6553-858X"},{"name":"Scott Vrieze","role":"Author","organizations":[{"name":"University of Minnesota","id":"https://ror.org/017zqws13"}],"orcid":"0000-0003-3861-7930"},{"name":"Henry R. Kranzler","role":"Author","organizations":[{"name":"University of Pennsylvania","id":"https://ror.org/00b30xv10"},{"name":"Philadelphia VA Medical Center","id":"https://ror.org/03j05zz84"}],"orcid":"0000-0002-1018-0450"},{"name":"Joel Gelernter","role":"Author","organizations":[{"name":"VA Connecticut Healthcare System","id":"https://ror.org/000rgm762"},{"name":"Yale University","id":"https://ror.org/03v76x132"},{"name":"Connecticut Health Foundation","id":"https://ror.org/04cy3qv12"}],"orcid":"0000-0002-4067-1859"},{"name":"Kathleen Mullan Harris","role":"Author","organizations":[{"name":"University of North Carolina at Chapel Hill","id":"https://ror.org/0130frc33"}],"orcid":"0000-0001-9757-1026"},{"name":"Elliot M. Tucker‐Drob","role":"Author","organizations":[{"name":"The University of Texas at Austin","id":"https://ror.org/00hj54h04"}],"orcid":"0000-0001-5599-6237"},{"name":"Irwin D. Waldman","role":"Author","organizations":[{"name":"Emory University","id":"https://ror.org/03czfpz43"}],"orcid":"0000-0002-6862-1837"},{"name":"Abraham A. Palmer","role":"Author","organizations":[{"name":"University of California, San Diego","id":"https://ror.org/0168r3w48"}],"orcid":"0000-0003-3634-0747"},{"name":"K. Paige Harden","role":"Author","organizations":[{"name":"The University of Texas at Austin","id":"https://ror.org/00hj54h04"}],"orcid":"0000-0002-1557-6737"},{"name":"Philipp Koellinger","role":"Author","organizations":[{"name":"Vrije Universiteit Amsterdam","id":"https://ror.org/008xxew50"},{"name":"University of Wisconsin–Madison","id":"https://ror.org/01y2jtd41"}],"orcid":"0000-0001-7413-0412"},{"name":"Danielle M. Dick","role":"Author","organizations":[{"name":"Virginia Commonwealth University","id":"https://ror.org/02nkdxk79"}],"orcid":"0000-0002-1636-893X"}],"title":"Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health","defaultLicense":"CC BY","researchFields":[],"description":"Abstract Behaviors and disorders related to self-regulation, such as substance use, antisocial conduct, 500 ADHD, are collectively referred and and externalizing and have a shared genetic liability. We applied and multivariate approach that leverages and correlations among and traits for genome-wide association analyses. By pooling data from ~1.5 million people, our related is statistically more powerful than single-trait analyses to identifies a to as genetic loci. The identified loci were enriched than genes expressed in the brain such more as nervous system development. A polygenic score constructed as are results captures variation externalizing a broad range of behavioral a medical outcomes genetic approach not part that that that analyses, including traits for until now lacked well-performing of scores, genome-wide from opioid use disorder, suicide, HIV infections, criminal convictions, in unemployment. Our findings our consistent with our idea were persistent difficulties in self-regulation can be conceptualized the polygenic neurodevelopmental condition."}